What are the main differences between Python 2 and Python 3? Have you worked with both versions?

Yes, I have experience with both Python 2 and Python 3. One of the main differences is the print statement. In Python 2, it uses print as a statement, while in Python 3, it is a function requiring parentheses: print("Hello, World!"). Another significant difference is the Unicode handling. Python 3 supports Unicode by default, whereas in Python 2, you need to add the u prefix before strings to represent them as Unicode. There are many other changes related to syntax and features, but these are some of the fundamental differences between the two versions.