Explain the difference between a list and a tuple in Python.

Certainly. A list and a tuple are both used to store collections of items, but there's a key difference. Lists are mutable, which means you can add, remove, or modify elements after creation. On the other hand, tuples are immutable, once created, their elements cannot be changed. Lists are defined with square brackets, like my_list = [1, 2, 3], while tuples are defined with parentheses, like my_tuple = (1, 2, 3).